Breast cancer is the most frequent cancer in women throughout the globe, and its management can be difficult due to its complex etiology.Treatment with chemotherapy, surgical 160 procedures, radiation treatment, and hormone therapy are among the most frequently utilized treatments.However, complications and resistance to multiple drugs can cause ch
Neurocognitive, psychiatric, and substance use characteristics in a diverse sample of persons with OUD who are starting methadone or buprenorphine/naloxone in opioid treatment programs
Abstract Background Medications for opioid use disorder such as opioid agonist treatment (OAT, including methadone, buprenorphine) are the gold standard intervention for opioid use disorder (OUD).Persons with OUD have high rates of neurocognitive impairment and psychiatric and substance use disorders, but few studies have examined these characteris
FOXA1 promotes tumor progression in prostate cancer via the insulin-like growth factor binding protein 3 pathway.
Fork-head box protein A1 (FOXA1) is a "pioneer factor" that is known to bind to the androgen receptor (AR) and regulate the transcription of COMBO STRAW BENT AR-specific genes.However, the precise role of FOXA1 in prostate cancer (PC) remains unknown.In this study, we report that FOXA1 plays a critical role in PC cell proliferation.The expression o
A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours
Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system.When these essential components are lacking, cancers develop the ability to subvert host immune surveillance allowing cancer cells t